GLP-1 PALYS A ROLE IN GLUCOSE CONTROL AFTER GASTRIC BYPASS

GLP-1 Plays Role in Glucose Control After Gastric Bypass

Last Updated: January 03, 2012.

 There is a positive association between glucagon-like peptide-1 (GLP-1) concentrations and insulin concentrations following gastric bypass surgery in patients with type 2 diabetes, suggesting a role for GLP-1 in glucose control, according to a study published in the January issue of Diabetes Care.
TUESDAY, Jan. 3 (HealthDay News) -- There is a positive association between glucagon-like peptide-1 (GLP-1) concentrations and insulin concentrations following gastric bypass (GBP) surgery in patients with type 2 diabetes, suggesting a role for GLP-1 in glucose control, according to a study published in the January issue of Diabetes Care.
Bart J. Van Der Schueren, Ph.D., of St. Luke's Roosevelt Hospital Center in New York City, and colleagues studied 15 obese patients with type 2 diabetes (one man, 14 women) before GBP surgery and one, 12, and 24 months following surgery. Glucose and GLP-1 concentrations were measured during an oral glucose challenge.
The researchers found that weight, glucose area under the curve from 0 to 180 min (AUC_0-180), insulin sensitivity index, and the homeostasis model assessment of insulin resistance all decreased significantly up to one year following GBP, but did not decrease any further at the two-year marker. The decrease in insulin AUC_0-180 became significant at the two-year point. GLP-1 AUC_0-180 was positively associated with insulin AUC_0-180. Glucose AUC_0-180 started decreasing in magnitude one month after surgery, while the GLP-1 AUC_0-180 increased in magnitude one month after GBP, but did not achieve increased variance until the one-year follow-up point.
"The association between GLP-1 and insulin concentrations supports the idea that the incretins are involved in glucose control after GBP," the authors write.